Sentences with phrase «tumour samples»

There is substantial clinical impact of performing genetic profiling of tumour samples in order to identify specific mutations and match those mutations with targeted therapies; one of the earliest forms of «personalised» or «precision» medicine.

In the new study, scientists at King's College London, led by Dr Anita Grigoriadis from the Breast Cancer Now Research Unit at King's College London, studied lymph node tissue and primary tumour samples from 309 breast cancer patients, who were treated between 1984 and 2002 at Guy's Hospital London.

Prostate cancer researchers have mapped the impact of an acquired mutation that alters epigenetic identity, the make - up of DNA, in about 50 % of patient tumour samples.

They then looked at tumour samples taken from lung cancer patients and found that high levels of MCT1 were linked to worse patient prognosis.

Scientists looked at tumour samples and found that the drug penetrates the core of the tumour as well as the surrounding areas which contain smaller numbers of cancerous cells.

Figure 2: Ternary plots of relative sensitivities to targeted kinase inhibitors for a cohort of primary tumour samples of chronic lymphocytic leukaemia (CLL).

In each person, the team found more than 100 mutations in the various tumour samples analysed; only about one - third of them occurred in all samples.

The team analysed levels of PTEN in around 500 ovarian tumour samples.

The authors of the work also show that NANOG is increased in patient - derived tumour samples from stratified epithelia.

Oncologists were then required to obtain government approval before sending tumour samples out of the country for testing.

In this film she describes her day - to - day role in the laboratory, processing tumour samples and setting up experiments to analyse DNA.

Clinical genomics involves the analysis of clinical tumour samples.

One of the OICR's major programs involves a registry that stores tumour samples linked to a complementary database.

In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high - grade serous ovarian cancer origin.

Scientists at The Institute of Cancer Research, London, analysed 177 tumour samples from patients with stage I non-seminomatous tumours enrolled in clinical trials through the Medical Research Council (MRC) Clinical Trials Unit.

The tumour samples contained many genetic changes, which constituted a «fingerprint» specific to each tumour.

«The mix of genetic faults within cancers has posed a major challenge in taking tumour samples that give a more accurate snap - shot of the disease.

Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples.

They were made after analysing more than 300 tumour samples from patients previously involved in the «MAX clinical trial», led by Associate Professor Niall Tebbutt, who directs the Medical Oncology Unit at Austin Health.