Sentences with phrase «tumour suppressor genes»

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Mutations of the VHL tumour suppressor gene in renal carcinoma.

The task is large but not insurmountable, says Rebecca: «One of the big problems with this cancer is that it doesn't have a recurrent driver gene — it's a disease dominated much more by multiple tumour suppressor genes being lost.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

«Over 40 % of prostate cancers lose PTEN and some lose both PTEN and another tumour suppressor gene, INPP4B, but we didn't previously have a clear picture of how this affects tumour growth,» says IMED Biotech Unit scientist Sabina Cosulich, at AstraZeneca.

Inherited mutations of the tumour suppressor gene CDKN2A are the strongest known risk factors for familial melanoma and mutations in this gene also increase the risk of other cancers.

RUNX3 is a tumour suppressor gene that prevents the formation of tumours by binding to DNA.

BRCA1 is a tumour suppressor gene involved in DNA repair through homologous recombination and in preserving the integrity of the genome.

The adenomatous polyposis coli (APC) gene is a tumour suppressor gene, i.e. a gene preventing uncontrolled cell growth that could lead to the formation of a cancer tumour.