Markers used included Islet - 1 and hermes for retinal ganglion cells,
Tyrosine Hydroxylase for amacrine cells, R5 for Müller glia, XAP2 for rod photoreceptors, and Calbindin for cone photoreceptors (Figure 2D, 2E, 2G, and 2H; Tables S3 and S4).
L - tyrosine is the substrate for the production of L - Dopa
by tyrosine hydroxylase, allowing survival of dopamine signaling neurons.
Researchers at Sweden's Karolinska Institute and at the National Institutes of Health are finding a connection
between tyrosine hydroxylase activity, thyroid hormone receptors, and depleted dopamine levels in the brain — particularly in the substantia nigra, a region associated with the movement difficulties characteristic of Parkinson's disease.11, 12,13
Accompanying this, vaccination with AFF 1 prevented 66 % of the loss
of tyrosine hydroxylase - staining (TH + — likely dopaminergic) neurons suffered by vehicle - treated mThy1 - AS mice (all Figure 1).
Tyrosine hydroxylase - immunoreactive axon length density / total neuron densities in select regions of striatum and globus pallidus for human, chimpanzee, gorilla, olive baboon, pigtailed macaque, and capuchin monkey.
Total neuron and length densities of
tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), and serotonin transporter (SERT)- immunoreactive axons in the frontal cortex (areas 4, 9, and 32) of humans, chimpanzees, and moor macaques.
Nr4a1 regulates the production of norepinephrine by limiting the amount of
tyrosine hydroxylase, the enzyme that controls a bottleneck in the biosynthesis of norepinephrine.
When Nr4a1 is missing,
tyrosine hydroxylase is highly expressed in monocytes and macrophages leading to more severe disease.
Neuronal Grafts: Human - derived dopamine neurons thrive in the brain of a monkey model of PD, testing positive for both dopamine transporter (green) and
tyrosine hydroxylase (red).
He went on to medical, and graduate neuroscience training at Harvard Medical School to write his PhD thesis on the neurochemistry of
tyrosine hydroxylase, the enzyme controlling dopamine biosynthesis.
Calcitriol, the hormonally active form of vitamin D, accumulates in the adrenals, and this stimulates the production of the gene for
tyrosine hydroxylase, which is involved in serotonin production.
Polymorphism in
the tyrosine hydroxylase (TH) gene is associated with activity - impulsivity in German Shepherd Dogs.
Abstract: Both D4 dopamine receptor (DRD4) exon 3 and
tyrosine hydroxylase (TH) intron 4 repeat polymorphisms have been linked to activity and impulsivity in German Shepherd Dogs (GSDs).
In ADHD rats that exercised, there was an increase in the expression of
tyrosine hydroxylase (TH) and brain - derived neurotrophic factor (BDNF), which are implicated in alleviating ADHD symptoms.