Sentences with word «ubiquitylation»

This is the first time an epigenetic signal has been shown to impact ubiquitylation and connects the patterns of epigenetic information in a new way.

Proteolysis in Cell Cycle and Cell Fate Decisions: How Ubiquitylation Coordinates Proliferation and Differentiation

STAT3 Ubiquitylation and Degradation by Mumps Virus Suppress Cytokine and Oncogene Signaling

The latest publication of the Robinson - lab (Lancaster University, UK) in collaboration with the Ettema - lab is now available online at Nature Communications, regarding the «Functional reconstruction of a eukaryotic - like E1 / E2 / (RING) E3 ubiquitylation cascade from an uncultured archaeon» — the first time that the ubiquitination cascade has been demonstrated outside of eukaryotes.

Targeting of HIF - α to the von Hippel - Lindau ubiquitylation complex by O2 - regulated prolyl hydroxylation.

Decreased mTORC1 activation and subsequent decreases in muscle protein synthesis, coupled with increased FOXO nuclear localization, increased transcription of atrophy - related genes, with up - regulated caspase 3 activation and muscle protein ubiquitylation provide a possible mechanism contributing to skeletal muscle loss in response to periods of negative energy balance.

A protein that is inactive in the absence of additional modification (s), such as phosphorylation or ubiquitylation.

As such, it appears that the insulin / IGF - PI 3K pathway not only regulates myofibrillar cleavage through caspase 3, but also the ubiquitylation of the resulting protein fragments via modification of ubiquitin - ligase expression.