DNA was stained with DAPI (chromosomes, blue): Chromosomes
interact with microtubules constituting mitotic spindle via kinetochores assembled on centromere region of chromosomes.
We hypothesize that differences between proteome
associated with microtubules in immature and mature fibers contribute to (1) microtubule reorganization and (2) myonuclei localization.
Mebendazole is thought to work by interference
with microtubules of intestinal cells in parasitic worms, thereby blocking the uptake of glucose and other nutrients, resulting in the immobilization and death of the helminths [6, 13].
To test the memristor theory, Tuszynski's team filled a
dish with microtubules, tubulin proteins and a buffer solution, then added electricity.
Once treated with tubacin, which makes the microtubules more chemically modified, the researchers observed a restoration in everything that went
wrong with the microtubules due to the toxin and stressor treatments.
For example, the protein PRC1
binds with microtubules, creating bundles of microtubules and cross-links between them.
The atomic structure from the NIH team could be fit into the lower - resolution 3D EM image reconstruction to identify the regions of the protein that interacted
with the microtubule surface.
The microscope image of the dorsal closure of a fly embryo shows alter - nating stripes of epithelial cells with aligned microtubule bundles (green) and epithelial cells
treated with a microtubule - destroying drug (blue).
«We know how motor proteins
interact with microtubules but how do you go from individual microtubules and motor proteins to large networked structures?»