"Orthologous" refers to genes that are similar in different species and descended from a common ancestral gene. These genes usually perform similar functions in the different species, despite some differences in their DNA sequences. Full definition
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Using data from the National Center for Integrative Biomedical Informatics (NCIBI)'s MiMI: (Michigan Molecular Interactions) which contains data from IntAct, DIP, BIND and others, we identified conserved and predicted novel protein - protein interactions (interologs or interologues) in human, mouse, fly, worm, and yeast based on interaction of orthologous proteins found in the other organisms. (ccri.uthscsa.edu)
Inferring nonneutral evolution from human - chimp - mouse orthologous gene trios. (nielsenlab.org)
It is important to realise that the ancestral element - based approach has its limits, as orthologous sequences between species have the potential to diverge beyond recognition. (journals.plos.org)