Sentences with word «orthologous»
"Orthologous" refers to genes that are similar in different species and descended from a common ancestral gene. These genes usually perform similar functions in the different species, despite some differences in their DNA sequences. Full definition
Using data from the National Center for Integrative Biomedical Informatics (NCIBI)'s MiMI: (Michigan Molecular Interactions) which contains data from IntAct, DIP, BIND and others, we identified conserved and predicted novel protein - protein interactions (interologs or interologues) in human, mouse, fly, worm, and yeast based on interaction of orthologous proteins found in the other organisms.
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Inferring nonneutral evolution from human - chimp - mouse orthologous gene trios.
It is important to realise that the ancestral element - based approach has its limits, as orthologous sequences between species have the potential to diverge beyond recognition.
The team then filtered these reads to enrich for orthologous DNA fragments.
Co-developed a method for determining orthologous genes in prokaryotes that can differentiate close paralogs using gene neighborhood context.
Co-developed a method for determining mammalian orthologous genes and their intron / exon boundaries using genome and mRNA data.
The SEED database was used to associate orthologous functions between the pseudomonad genomes.
Rapidly diverging short genes, even when they are evolutionarily orthologous to genes in other species, may be nearly impossible to classify as such.
Orthologous ORFs for Lcn16 and Lcn17 are found in the same orientation in the rat genome, but synteny is disrupted around this location in the primate lineage and there are no orthologues present in primates or the human genome.
When orthologous proteins were compared between these two populations, the same pattern emerged — proteins from the smaller populations were more flawed than those from the free - living bacteria of the same species.
Functional analysis using clusters of orthologous groups of bacteria target proteins suggests that flavonoids regulate the metabolism of gut microbiota [147].
Pepper explains, «One of the exciting things about this approach is that it employs a widely used, well - supported, off - the - shelf bioinformatics software known as Stacks (written by Julian Catchen at the University of Oregon) as a «filter» to enrich for pairs of fragments that are likely to be alleles of a single, orthologous region, rather than paralogs or homeologs.»
Positive selection in the human genome inferred from human — chimp — mouse orthologous gene alignments.
Orthologous proteins often perform the same function, but in different species.
Three data sets of orthologous genes from eighteen genomes were aligned using default parameters using CLUSTALW53 and poorly aligned regions were excluded using Gblocks54.
Inferring nonneutral evolution from human - chimp - mouse orthologous gene trios Clark, A. G., S. Glanowski, R. Nielsen, P. D. Thomas et al. 2003.
«However, because SIF - seq only requires DNA sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large genomic region from human to the neuronal enhancers present in the orthologous chimpanzee region.
Positive selection in the human genome inferred from human — chimp — mouse orthologous gene alignments Clark, A. G., S. Glanowski, R. Nielsen, P. Thomas et al. 2003.
According to Pepper, «A problem arises when our computational methods accidentally align DNA regions that are duplicated within the genomes of the plants being studied, rather than mapping the orthologous regions between the plants.»
STRING assigns quality scores to each of these interactions, which allow the very different evidence types to be combined, and automatically transfers interactions to orthologous protein pairs in other organisms.
This histidine is highly conserved in the orthologous proteins of all mammals and in many other species indicating that it is likely to be functionally important.
Ts65Dn mice are trisomic for about two - thirds of the genes orthologous to human chromosome 21 and are a well - characterized model for studying Down Syndrome.
This is only done for the antibodies corresponding to genes where the mouse and human genes are orthologous.
A computational analysis of 106 orthologous proteins confirmed their hypothesis that proteins from species with smaller populations were more vulnerable in water.
Though these shared, «orthologous» proteins are identical in shape and function, genetic differences alter them in more subtle ways.
RESULTS: Transcription of the MAOA gene in rhesus monkeys is modulated by an orthologous polymorphism (rhMAOA - LPR) in its upstream regulatory region.