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A second mouse model, induced by overexpression of IL - 17 in skin, also shows bone loss, and suggests that the deregulation of the protein is sufficient to cause this effect. (sciencedaily.com)
Due to overexpression of genes in trisomic cells, abnormal neuronal development and functional changes occur in the central nervous system of DS patients. (journalmc.org)
Wild - type mouse microglia respond in a dose - dependent fashion to HS - oligosaccharides isolated from MPS IIIB patients with overexpression of macrophage inflammatory protein 1α (Mip1a or Ccl3) and interleukin 1β mRNAs. (journals.plos.org)