These differences suggest that adapting to exercise involves many processes, but scientists have observed that one gene in particular, peroxisome proliferator - activated receptor - gamma coactivator PGC - 1α, controls many of them. (sciencedaily.com)
The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown). (jci.org)
It is a required coactivator of TGF - beta, Notch and nuclear receptor genes. (salk.edu)