A coactivator is a substance or protein that works together with another substance or protein to enhance or amplify its activity or function. Full definition
These differences suggest that adapting to exercise involves many processes, but scientists have observed that one gene in particular, peroxisome proliferator - activated receptor - gamma coactivator PGC - 1α, controls many of them. (sciencedaily.com)
The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown). (jci.org)
It is a required coactivator of TGF - beta, Notch and nuclear receptor genes. (salk.edu)