We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig. (stke.sciencemag.org)
(B) Model for the role of ABL kinases in the regulation of breast cancer bone metastasis. (stke.sciencemag.org)
Here, we uncovered a critical role for ABL kinases in the regulation of breast cancer metastasis to bone. (stke.sciencemag.org)