However, global mortality remains high for many patients with advanced tumors. (blog.feedspot.com)
Earlier studies haven't found this to be the case, but they were plagued by self - selection: Women with more advanced tumors tend to avoid having babies, so those who did become pregnant may have had a better average prognosis. (sciencemag.org)
Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.?? (grantome.com)