If the amount of miRNA were quantified in an HD patient, the amount could provide insight into the likely age of disease onset or life expectancy of the patient which current genetic testing in HD does not provide,» added Myers. (sciencedaily.com)
In families affected with SCA1, the number of CAG repeats increases with each generation, correlating with increased severity and an earlier age of disease onset. (jax.org)
Over the following years, he and his colleagues cloned the HD gene, located its stretch of repeated DNA, showed that the size of that stretch is correlated with age of disease onset and age of death, described how it causes disease, and identified genetic factors that affect how quickly symptoms develop. (ashg.org)