Signaling through CD28 and CTLA - 4 controls two distinct forms of T cell anergy. (cellr4.org)
Noteworthy is that «Another possible explanation for why late introduction of cereal grains was associated with wheat allergy is that when wheat is introduced to an older child, it tends to be introduced in greater amounts.18 We can speculate that a large antigen load may have resulted in T - cell activation instead of anergy or tolerance.» (wholesomebabyfood.momtastic.com)
If it does, then you might use the approach of making more beta cells right at early onset of the type 1 disease to try and stop or reverse the immune attack, making the immune system think its made a mistake, inducing something called anergy by making more beta cells. (stembook.org)