Breast Cancer: CXCR4 plays an important role in breast cancer progression by enhancing tumor growth, tumor cell invasion, and metastasis to bone and lung. (thno.org)
Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada, A, Zhao R, Milstien S, Zhou H, Spiegel S, and Takabe K. Sphingosine -1-phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis. (roswellpark.org)
An Improved Syngeneic Orthotopic Murine Model of Human Breast Cancer Progression Breast Cancer Research and Treatment 2014 Oct; 147 (3): 501 - 12. (roswellpark.org)