The structure reveals key interactions that probably contribute to the high catalytic efficiency of this enzyme relative to other flaviviruses, indicating promising starting points for drug design. (science.sciencemag.org)
β - Lactamases encoded by reconstructed sequences corresponding to the GNCA node have been previously shown11 to be able to degrade a variety of antibiotics, including penicillin and third - generation antibiotics with efficiencies similar to that of a modern average enzyme (by contrast, the modern TEM - 1 β - lactamase is a specialist enzyme that displays high catalytic efficiency with penicillin and a substantially lower efficiency with third - generation antibiotics). (nature.com)
Efforts to improve catalytic efficiency and co-localization of ribozymes with their targets in mammalian cells are still an ongoing effort in the lab. (cityofhope.org)