For example, up - regulated influx transporters (OCT3 and OCTN1) localized at the apical membranes of Sertoli cells could mediate the transport of the drug compound 9 from the lumen into the basolateral compartment of Sertoli cells, where the up - regulated efflux transporters (ABCB1 / p - glycoprotein, ABCB8, ABCB9, ABCC5, and ABCC10) could then transport the drug out of Sertoli cells against a concentration gradient, resulting in enhanced efficiency of recovery upon cessation of treatment. (academic.oup.com)
These were as follows: diarrhoea (four dogs; severe enough to warrant cessation of treatment in one dog); vomiting (four dogs); fever, lethargy and cystitis (one dog); an inflamed footpad and vomiting (one dog); and diarrhoea, vomiting and lethargy (one dog).» (dogsnaturallymagazine.com)
To begin to explore possible molecular mechanisms by which longer exposure to a drug might result in a more rapid recovery following cessation of treatment, we made note of a study reporting changes in the levels of expression of efflux and influx membrane transporters in testes after oral administration of adjudin (27). (academic.oup.com)