Increased SQLE expression promotes the biosynthesis of cholesteryl ester, which induces NAFLD - HCC cell growth. (stm.sciencemag.org)
In these studies, atherosclerosis was associated with the diet - induced enrichment of LDL with cholesteryl oleate. (academic.oup.com)
Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function. (stm.sciencemag.org)