«Since our study only looked at common gene variants, the total genetic overlap between the disorders is likely higher,» explained Naomi Wray, Ph.D., University of Queensland, Brisbane, Australia, who co-led the multi-site study by the Cross Disorders Group of the Psychiatric Genomics Consortium (PGC), which is supported by the NIH's National Institute of Mental Health (NIMH). (sciencedaily.com)
Psychiatrist Jon McClellan and geneticist Mary - Claire King, both of the University of Washington, Seattle, wrote earlier this month that genome - wide association studies (GWAS), which scan large stretches of the genomes of hundreds of people for common gene variants driving common diseases, aren't getting us very far. (sciencemag.org)
Since the GWAS approach is designed to identify relatively common gene variants and it has been proposed that OCD and TS might be influenced by a number of rare variants, the research team adopted a different method. (uchospitals.edu)