The second component of the pathway occurs after the target is reached. (link.springer.com)
Over the past several years, researchers in the lab of Whitehead Member David Sabatini have been identifying the many key components of the pathway — whose deregulation is associated with diseases ranging from diabetes to cancer to epilepsy — moving ever closer to finding precisely how mTORC1 actually senses the presence of amino acids. (sciencedaily.com)
«We had been studying components of this pathway for several years,» said senior author Dr. Andrea Ballabio, professor of molecular and human genetics at Baylor College of Medicine and Texas Children's Hospital in Houston, Texas, and director of the Telethon Institute of Genetics and Medicine in Naples, Italy. (sciencedaily.com)