The Pax3 protein, which is encoded by the Pax3 gene, regulates neural tube closure and cardiac neural crest development by blocking the activity of p53, which is a cell - death protein. (joslin.org)
They scientists said if the timing of crest development is associated with «intense intrasexual competition» among male primates (where members of the same sex compete for mates), we could look back to the fossil record to see if a similar picture emerges among our extinct ancestors that also had sagittal crests. (newsweek.com)
A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins. (science.sciencemag.org)