Malignant cases of GII revealed strong positive expression of Cyclin D1 in invasive ductal epithelial cells and stroma, while negative stain was seen in the invader cells with vesicular polymorphic nuclei (Figure 2C). (oncm.org)
It is critically important to understand how a genetic pathway actually functions and the consequences of interrupting it, especially in this case where there are multiple drug inhibitors of cyclin D being tested in clinical trials for breast cancer. (sciencedaily.com)
The researchers concluded from these findings that aberrant activation of cyclin E / Cdk2 oncogenic signaling is essential for maintaining and expanding the CD44 + / CD24 - / Low subpopulation in inflammatory breast cancer. (sciencedaily.com)