Radu and Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway (DNP) and the nucleoside salvage pathway (NSP). (sciencedaily.com)
The authors also found that a novel small molecule inhibitor of the salvage pathway enzyme deoxycytidine kinase blocked leukemia growth in mice in combination with thymidine (to inhibit the de novo pathway). (sciencedaily.com)
DNA methylation inhibitor 5 - Aza - 2» - deoxycytidine induces reversible genome - wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. (abcam.com)