Such a finding suggested that the treatment of EGFR - related lung cancers with the usual small molecule inhibitory drugs would not be successful (patients harboring these mutations are typically resistant to these drugs), while antibodies that interfere with dimerization of EGFR would be effective. (sciencedaily.com)
After induction of interferon - stimulated genes (ISGs), the ubiquitin - specific protease USP18 docks to the receptor complex via STAT2, thus interfering with receptor dimerization and STAT phosphorylation. (biologie.uni-osnabrueck.de)
It contains motifs that are responsible for dimerization, nuclear translocation and binding to NF - κB - binding motifs that are present in DNA. (nature.com)