They travel through the bloodstream to impact the expression of genes on distant tissues, which impacts how our bodies function. (taliand.com)
McDonald and close collaborators from Memorial Sloan Kettering Cancer Center and Johns Hopkins University School of Medicine sought to understand how pancreatic cancer progresses from a primary tumor in the pancreas to metastatic disease in distant tissues. (sciencedaily.com)
Microvascular endothelial cells play a critical role in tumor progression and metastasis by forming capillary networks that encourage tumor growth and by promoting the attachment of circulating tumor cells to the vascular wall of distant tissues. (cancerres.aacrjournals.org)