Wnt proteins, regulators of development in many organisms, bind to seven transmembrane — spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled - mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients. (science.sciencemag.org)
A long - standing goal of our group is to elucidate the role of endocytosis in cell signalling and cancer. (ifom-ieo-campus.it)
High rates of endocytosis by small intestinal cells have been reported for lectins of all types. (foodsafetymagazine.com)