Sentences with word «endocytosis»
Wnt proteins, regulators of development in many organisms, bind to seven transmembrane — spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled - mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients.
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A long - standing goal of our group is to elucidate the role of endocytosis in cell signalling and cancer.
High rates of endocytosis by small intestinal cells have been reported for lectins of all types.
A research team headed by Daniël van Damme and Geert De Jaeger from VIB and Ghent University (Belgium), and Staffan Persson from the Max Planck Institute of Molecular Plant Physiology in Golm near Potsdam (Germany) has now identified a new protein complex which is crucial for endocytosis in plants.
Their study New Tools for «Hot - Wiring» Clathrin - Mediated Endocytosis with Temporal and Spatial Precision has just been published in The Journal of Cell Biology.
Endosomes are machinery that tumor cells, via a process called endocytosis, can use to incorporate components into their environment and obtain energy by degrading them via autodigestion or autophagy.
Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.
We call the process of triggering endocytosis «hot - wiring» because it is similar to just twisting the wires together rather than having a key.
«Ultrafast endocytosis at mouse hippocampal synapses.»
A cell can change the amount of these cell surface proteins by internalizing small portions of the membrane through endocytosis.
A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.
She still runs an eight - person lab, studying endocytosis with four grad students who probably don't have to attend as many lab meetings as they used to.
As endocytic proteins such as F - BAR have been found to play a role in cortical actin waves, the researchers sought out to understand the link between endocytosis and cortical actin waves.
A solution to the problem of creating endocytosis on demand is being compared to «hotwiring» a car.
We have shown that the ubiquitous clathrin heavy chain (CHC), well characterized for its role in intracellular membrane traffic and endocytosis from the plasma membrane (PM), forms large plaques connected to α - actinin and actin filaments.
The team also solved the problem of knowing where endocytosis will happen on the cell.
«Scientists create endocytosis on demand by «hotwiring» cells: Discovery could be used to «feed» cells with drugs or nanoparticles.»
Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have found that the protein hinders a key step involved in the transmission of neuronal signals, which is essential for higher - brain functioning: vesicle endocytosis at the nerve terminal.
«Ultrafast endocytosis at the C. elegans neuromuscular junction.»
Tumour suppressor RNF43 is a stem - cell E3 ligase that induces endocytosis of Wnt receptors.
✓ Neurotoxicity: WGA can cross your blood - brain barrier33 through a process called «adsorptive endocytosis,» pulling other substances with it.
Receptors display a wide range of state - dependent endocytosis rates, but the functional significance of these patterns was not understood.
Among all the genes that control endocytosis, the authors of the study focused specifically on one, called RAB7; this gene is highly expressed in melanoma cells.
Our contributions to this field have helped to change the way endocytosis is perceived, from being simply a mechanism for signal attenuation to being a vital component of the cell signalling machinery that provides spatial and temporal dimensions to signalling events (1).
These two processes promote endocytosis of Smo in clathrin - coated pits.
These viruses enter cells using «clatherin endocytosis.»
To initiate endocytosis, adaptor proteins need to recognize specific areas of the membrane to be internalized.
«Non-small cell lung cancers can be sorted in clusters by endocytic changes: Sorting cancer by defective endocytosis genes.»
Cell biologists have studied for decades how endocytosis works however up till now they have found it impossible to control the process.
Whereas the chemical across the cell the light can be focused in a narrow region causing endocytosis to be triggered only in that region.
The UT Southwestern researchers monitored endocytosis in NSCLCs and found significant heterogeneity among the various cell lines, underlining the astounding variety and personal nature of cancer types.
Their results, say the UT Southwestern researchers, show that changes in endocytosis reflected by the expression of important molecules on the cell surface can be used to distinguish cancer subtypes.
The OIST researchers found that when endocytosis is inhibited, high - frequency transmission breaks down much more quickly than it would under normal circumstances.
«If you inhibit [endocytosis in the nerve terminal], then the vesicle recycling becomes slower and the supply of the vesicles is inhibited,» OIST Professor Tomoyuki Takahashi from the Cellular and Molecular Synaptic Function Unit explains.
Our studies on the molecular mechanisms of endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.