Human intestinal organoids (HIOs) generated in the hydrogel matrix differentiate into mature intestinal tissue and present specialized human intestinal cell types, such as enteroendocrine cells (CHGA; red), after transplantation into an animal. (sciencedaily.com)
Along with intestinal stem cells, the team identified differentiated nutrient - digesting and absorbing enterocytes, mucus - producing Goblet cells, hormone - secreting enteroendocrine cells, and microbiome - regulating and sensing Paneth cells, and they performed a series of assays that confirmed their functions. (sciencedaily.com)
During observation and analysis of the now in vivo organoids, study authors looked for signs of posterior region enteroendocrine cells, which make hormones found in naturally developed human colon. (sciencedaily.com)