In a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changes. (sciencedaily.com)
«We also found that this variant, H3.3, is modified by methylation to create a specific epigenetic landscape that is accommodated by the tumor - suppressing protein ZMYND11. (sciencedaily.com)
Targeting ecRNAs in the brain could be an attractive therapeutic approach to reorganizing epigenetic landscapes at specific genes, thus alleviating longstanding pathologies associated with dysfunctional methylation patterns. (sciencedaily.com)