Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans. (researchmatch.org)
The problem was an enzyme called soluble epoxide hydrolase (sEH), which breaks down and inactivates EDP. (sciencedaily.com)
To make this discovery, Serhan and colleagues deconstructed the biosynthetic pathway for maresin biosynthesis and found that human macrophages are responsible for converting DHA to the novel epoxide intermediate «13S, 14S - epoxy - maresin.» (sciencedaily.com)