Now research in mice is showing that human embryonic stem cells differentiated into medial ganglionic eminence (MGE)- like cells, which produce GABA, may help alleviate two of the most severe side effects — chronic neuropathic pain and bladder dysfunction. (sciencedaily.com)
When we overexpress the homeobox transcription factor Dlx2, or the basic helix - loop - helix transcription factor Ascl1, we obtained neurons that exhibited action potential discharges typical for interneurons generated in the medial ganglionic eminence, where these two transcription factors are also expressed during development. (abcam.com)
Elevated tau is associated not just with Alzheimer's but with a range of lesser - known neurodegenerative diseases, such as progressive supranuclear palsy and corticobasal ganglionic degeneration. (sciencedaily.com)