MYC is a key driver of cancer cell metabolic adaptations after CDK4 / 6 inhibition, which includes upregulation of glutaminase 1 (GLS1) and mTOR ‐ dependent pathways. (msb.embopress.org)
«We found that targeting only glutaminase will miss the less aggressive ovarian cancer cells because they are at a metabolic stage where they are not yet glutamine - dependent.» (sciencedaily.com)
Two mitochondrial enzymes — pyruvate carboxylase (PC) and glutaminase replenish carbon to the Krebs cycle. (sciencedaily.com)