The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission. (sciencedaily.com)
And while some, including a 2013 study in the journal The Lancet and a 2015 paper in the journal Nature, have yielded some promising clues, none have been able to spot any precise, reliable genetic hallmarks of the disease. (businessinsider.com)
This aberrant brain circuitry — the amyloid plaques and tau tangles — became the twin hallmarks of the disease that bears his name. (discovermagazine.com)