Takagi was approached by Prof. Atsuko Yamashita at Okayama University who had been studying the T1r2 - T1r3 heterodimer of medaka fish for years. (sciencedaily.com)
PPARs form heterodimers with the retinoid X receptor (RXR) and regulate transcription of their target genes and gene networks. (sbpdiscovery.org)
For preparation reasons of the receptors, the group chose to study the medaka fish T1r2 - T1r3 heterodimer over the human version. (sciencedaily.com)