In dogs with normal sugar metabolism, glucose in the lens is metabolized by an enzyme called hexokinase into small molecules that diffuse out of the lens. (drnelsonsveterinaryblog.com)
By blocking the enzyme hexokinase, it prevents glucose phosphorylation. (fitnessandpower.com)
While all humans have this fifth hexokinase, it appears during pregnancy, women with less of this gene are not able to metabolize glucose as well, the study showed. (sciencedaily.com)