The poor apparent coverage was the result of high sequence divergence of the TMAdV genome from SAdV - 18, which hindered the identification of most of the 16,524 actual deep sequencing reads derived from TMAdV (Fig. 2B, red). (journals.plos.org)
«Multiple displacement technology uses an enzyme which has a very high processivity and is a really high - fidelity enzyme, so we can ensure uniform coverage during the process... and a very high sequence accuracy,» says Langsdorff. (sciencemag.org)
It has a small genome (about 2 x Arabidopsis) with high sequence identity (average 92 %) with (semanticscholar.org)