In two years, Darst published the first low - resolution structures of E. coli RNA polymerase in combination with the sigma factor molecule that guides it to the correct starting place on the gene, a molecular complex called holoenzyme. (sbgrid.org)
When the PP2A catalytic C subunit associates with the A and B subunits several protein isoforms, namely holoenzymes, are produced with distinct activity and substrate specificity. (sciencedaily.com)
The project focuses on the dynamics of transient microcompartments formed by the V - ATPase holoenzyme, V - ATPase subcomplexes and subunits together with the mentioned proteins, with the aim to understand the mechanisms leading to this unique type of physiologically relevant regulation. (biologie.uni-osnabrueck.de)