His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation. (eurosystemproject.eu)
The best - studied class of homeobox - containing genes are the Hox genes, usually found clustered next to each other along animal chromosomes. (fossilmuseum.net)
It has been known for quite some time that NPM1mut AMLs are associated with the activation of the so - called homeobox (HOX) stem cell genes. (sciencedaily.com)