The pathogenetic background of this additional alteration is completely unknown, but it is speculated that the mutant - FLT3 receptor homodimers in patients with loss of wt - FLT3 have a stronger transforming capacity compared to mut / wt heterodimers. (dresden-ipp.de)
Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ. (lji.org)
Point mutations of a putative phosphorylation site can specifically abrogate transcriptional activity of a specific homodimer assembly, with little effect on other configurations. (journals.plos.org)