David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of functional human platelets. (sciencedaily.com)
The findings, published April 28 in Cell Metabolism, are the first comprehensive lipidomic profile of human platelets in response to stimulation and aspirin treatment. (sciencedaily.com)
DG041 is a novel, first - in - class, orally - administered small molecule which has been shown in preclinical studies to be a selective and potent antagonist of the EP3 receptor for prostaglandin E2 (PGE2), inhibiting human platelet aggregation in a dose - dependent manner. (decode.com)