By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT. (sciencedaily.com)
New findings implicate ECM29 ‐ dependent proteasome hyperactivation in senescence induced by the anti ‐ breast cancer drug palbociclib. (emboj.embopress.org)
In line with our in vitro data, Pkn1 — / — mice showed AKT hyperactivation, elevated NeuroD2 levels, and reduced expression of PF - PC synaptic markers during stages of PF maturation in vivo. (jci.org)