Sentences with word «hyperactivation»

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

New findings implicate ECM29 ‐ dependent proteasome hyperactivation in senescence induced by the anti ‐ breast cancer drug palbociclib.

In line with our in vitro data, Pkn1 — / — mice showed AKT hyperactivation, elevated NeuroD2 levels, and reduced expression of PF - PC synaptic markers during stages of PF maturation in vivo.

They identified four pathogenic variants in DEPDC5, two in NPRL2, and one in NPRL3 and showed hyperactivation of the mTORC1 pathway in brain tissue from patients with NPRL2 and NPRL3 mutations.

Historically, drug development activities in this space have focused on blocking mTORC1 activation, in part because hyperactivation of the pathway can lead to aberrant growth seen in cancer or metabolic abnormalities associated with diabetes.

By binding not only CD28 but also its coligand B7 - 2 directly, superantigens potently enhance the B7 - 2 / CD28 interaction, inducing thereby T - cell hyperactivation.

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.

Upon investigating the underlying molecular mechanism, they observed that mTORC1 hyperactivation enhances the level of the stress hormone FGF21 by depletion of the amino acid glutamine.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

Furthermore, both mTOR hyperactivation and autophagy suppression were observed in kidney specimens from obese patients with kidney disease.

The analysis revealed that while performing working memory tasks, the young patients with concussion had initial activation that was greater than normal, known as hyperactivation, compared to young controls in the right precuneus and right inferior parietal gyrus of the brain, whereas the older patients had hypoactivation (less than normal) compared to older controls in the right precuneus and right inferior frontal gyrus.

Catalase abrogates ß - lapachone - induced PARP1 hyperactivation - directed programmed necrosis in NQO1 - positive breast cancers.

Brain functional correlates of working memory: reduced load - modulated activation and deactivation in aging without hyperactivation or functional reorganization.

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

She says that frequently exposing older people to foreign plasma may be unsafe, because hyperactivation of their immune systems could lead to autoimmune or inflammatory disease.

ST2 contributes to T - cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

By inhibiting AKT with MK - 2206 and siRNA - mediated knockdown, we found that AKT hyperactivation is responsible for the elongated axons, higher NeuroD2 levels, and reduced density of presynaptic specifications in Pkn1 — / — Cgcs.

In addition, many cancer cells express insulin receptors (IRs) and show hyperactivation of the IGF1R - IR pathway.

Their findings thus pointed to hyperactivation of UBE3A as the likely cause of this child's autism.

These unexpected findings may be related to the epileptic phenotype of many pedigrees of patients with early - onset familial AD and to the hyperactivation of neuronal networks in patients with sporadic AD and amyloid - positive nondemented subjects.

These findings are probably related to the epileptic phenotype of many pedigrees of patients with early - onset familial AD and to the hyperactivation of neuronal networks in patients with sporadic AD and amyloid - positive nondemented subjects.

Researchers generally attribute tissue thickening (and ensuing damage to small blood vessels) to hyperactivation of skin cells called fibroblasts.

Often, living in a pernicious environment leads to hyperactivation of our immune gut cells and what would normally not cause an immune response, now does.

This hyperactivation results in threats detected in nearly every interpersonal transaction.

Furthermore, this hyperactivation intensifies negative emotional responses to these threats and results in excessive rumination about threats (Mikulincer et al. 2003).

This hyperactivation is initiated by the individual's confusion about the viability of seeking proximity when they need help from their attachment figures, and are impacted extensively by their internal working models.