«This work was exciting because we replicated the previous finding of neuron hyperexcitability in neurons derived from a new cohort of patients diagnosed by a different psychiatrist, confirming the robustness of this characteristic and its potential use for drug development,» says Renata Santos, co-first author and a Salk research collaborator. (sciencedaily.com)
Now, Klyachko and Pan-Yue Deng, MD, PhD, an assistant professor of cell biology and physiology, have identified a separate mechanism that also results in neuronal hyperexcitability: an increase in the baseline flow of sodium ions into neurons. (sciencedaily.com)
Working with motor neurons derived from ALS patients and healthy controls, Dr. Wainger performed fundamental electrophysiological characterization and identified motor neuron hyperexcitability in ALS patient - derived motor neurons (Wainger et al., 2014). (mghmind.org)