In this manuscript, we focused the role of miR - 142, one of the miRNAs upregulated in human BCSCs, and found that miR - 142 targets APC, up - regulates the Wnt signaling, and induced the expression of miR - 150 that has an ability to induce hyperproliferation of mammary tissues. (elifesciences.org)
Helicobacter pylori induces hyperproliferation in a three - dimensional culture system in conjunction with up - regulation of ß - catenin target genes. (vicc.org)
In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer. (vicc.org)