An individual's condition will be considered «grievous and irremediable» if it is serious and incurable, has put them in an «advanced state of irreversible decline in capacity», has caused them intolerable, enduring physical or psychological suffering, and where their natural death is reasonably foreseeable. (ngariss.com)
Numerous issues that NAE addressed resembled the equally «numerous promulgations emanating over the decades from the offices of the liberal Protestant establishment that is now in apparently irreversible decline,» he observed. (firstthings.com)
Huntington's disease is a dominantly inherited, neurodegenerative disease causing irreversible decline in mood, memory and movement. (hdfoundation.org)