Pairwise tests among six isogenic lines ofDrosophila melanogaster were performed to determine whether there is a genotype - specific interaction in the success of sperm. (science.sciencemag.org)
This study defines a network of synthetic sick / lethal interactions with a set of query genes in a series of isogenic cancer cell lines. (msb.embopress.org)
Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context. (sciencemag.org)