The scientists also found that children with congenital heart disease carry large numbers of mutations in genes that are active during brain development. (hhmi.org)
In cases where there are lots of T cells in the vicinity of a tumor, or where tumor cells have undergone large numbers of mutations, which creates additional targets for immune sentries, T cells will signal a full - fledged immune response to the cancer. (sciencemag.org)
Cancer cells that have a relatively large number of mutations in their DNA express aberrant proteins — or neoantigens — that reveal the cancer to the immune system. (sciencedaily.com)