They previously showed that depletion of HDAC3 in mouse liver upregulates expression of many genes involved in lipid synthesis, which causes a remarkable fatty liver. (sciencedaily.com)
The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly. (science.sciencemag.org)