Discontinue the use of macrocyclic lactones as a «slow kill» protocol for known heartworm infections; it is NOT recommended by the American Heartworm Society. (heartwormsociety.org)
Unfortunately, the use of macrocyclic lactones for generalized demodicosis is considered extralabel, and there is no antidote to the potentially serious and life - threatening side effects. (2ndchance.info)
Macrocyclic GBCAs were originally developed as a safer alternative to linear GBCAs. (sciencedaily.com)