The phrase "major breakthrough" means a significant and important discovery or achievement that brings about significant progress or change in a particular field or situation. Full definition
It is nearly impossible at present to make major breakthroughs in science without working in collaboration. (sciencedaily.com)
But with new findings about our microbial inhabitants emerging every month, major breakthroughs for targeting any number of chronic inflammatory diseases, metabolic and mood disorders may be around the corner. (theglobeandmail.com)
Both of these projects have the potential to make major breakthroughs in animal health care and transform the current system into a more comprehensive integrated approach to veterinary medicine. (gcci.org)